Document Details

Document Type : Project 
Document Title :
Design and synthesis of some phthalimide derivatives for hypoglycemic activity
تصميم وتحضير بعض مشتقات الفثاليميد لاختبارها في علاج السكري
 
Subject : Design and synthesis of some phthalimide derivatives for hypoglycemic activity 
Document Language : Arabic 
Abstract : The synthesis and biological evaluation of some pthalimide derivatives as oral hypoglycemic showed appreciable glucose lowering effects in alloxinized diabetic rats. Some N- [4- (phthalimidoalkyl) phenylsulfonyl] –N' –cyclohexylurea and N- [4-phthalimidophenylsulfonyl]-N' -alkylurea were prepared and tested for their hypoglycemic action. Some of them showed strong and long acting hypoglycemic. Some of the reported phthalimido is comparable to, and in few cases higher than that exhibited by the well known drug: Glyburide. On the light of molecular modeling studies, it is expected that the designed compounds have shown good matching with the glyburide prototypic compound and may show better hypoglycemic activity where what we believe the pharmacophoric moiety, [p (2-aryl sulfonamidoethyl)] group, which is seen in glyburide and other second generation hypoglycemic will be attached to the phthalimido nucleus, a modification which may refine the second generation hypoglycemics from its side effects. However, we shall try to attach the same pharmacophore but using one and two or zero methylene groups in order to explore the activity to some extent and shed some light about structure activity relationship of such interesting design and promising class of compounds. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Tuesday, June 29, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
محمد أيمن الذهبيAlzahaby, Mohamed AymanInvestigatorDoctorate 

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 27193.docx docx 

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