Document Details

Document Type : Project 
Document Title :
Study of the Toxic Effects of
دراسة التأثيرات السمية لمادة الأكريلامايد على الجهاز العصبي
 
Subject : Study of the Toxic Effects of 
Document Language : Arabic 
Abstract : The identification of the harmful effects of the acrylamide (ACR) on man health, especially the children, has widely increased in last years. Acrylamide is a water-soluble vinyl monomer, which is commonly used in many industrial fields. Occupational exposure of humans and experimental intoxication of laboratory animals with acrylamide produces a neurotoxic syndrome characterized by ataxia, skeletal muscle weakness and weight loss. Recently, it has been reported that the acrylamide monomer is formed in certain foods principally from the interaction of the amino acid asparagine with glucose or other carbohydrates cooked at high temperatures; the highest concentrations of acrylamide have been identified in potato chips, French fries and grain-based foods that are cooked at very high temperatures during frying, grilling or baking. According to the reports issued in 2002 by the food and Agriculture Organization (FAO) and World Health Organization (WHO), it has been observed that cumulative oral doses of 500-600 mg/kg of acrylamide using daily doses of 25-50 mg/kg/day are required to produce ataxia in rats. Smaller daily doses of acrylamide do not produce a clinical effect until a larger cumulative dose is attained. The overall daily intake in human is around 0.3–0.8 μg/kg/day. In view of such harmful effect of acrylamide, especially nowadays, where many families depend essentially in their nutrition on the ready made, home delivery and fast foods, it is critically important to analyze the neurotoxic effects of acrylamide according to different doses and different time schedules. The present research proposal will involve the examining of the structural changes in different parts of the nervous system of adult male rats under oral and parentral intake of acrylamide treated with different doses of and different durations. At the end, this research project will be of great value to many specialists of Nutritional Medicine, Internal Medicine, Pediatrics and Neurosciences to lay the focus on the abuse of acrylamide, which is increasingly taken under the wide demand of our recent life. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Monday, June 28, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبد المنعم عبد السلام الحيانيAl-Hayani, Abdulmonem ِAbdussalamInvestigatorDoctorate 

Files

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 27170.docx docx 

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