Document Details

Document Type : Project 
Document Title :
Estrogenicity of Outer Scales of Onion and Garlic on Reproductive functions of Mice
الـتأثير الاستروجيني للقشرة الخارجية للبصل و الثوم على وظائف أعضاء التكاثر في الفئران
 
Subject : Estrogenicity of Outer Scales of Onion and Garlic on Reproductive functions of Mice 
Document Language : Arabic 
Abstract : Endocrine disruption is a major global health concern in the industrialized world. There is an increasing demand for natural compounds that improve women’s health by mimicking the critical benefits of estrogen to the bones and the cardiovascular system but avoiding its deleterious effects on the breast and uterus. Many plants have been used by the local communities for the treatment of a large number of ailments. The folk medicine has always the upper hand in the treatment of widely spread diseases among local communities. Onion and garlic are worldwide-consumed vegetables. Traditional way of their preparation for direct consumption at home and for processing in food industry includes peeling off the dry skin. Dry peels are not processed and are forming the waste. Because of beneficial activities for human health it would be justified to use this waste product. This is the first study to indicate that outer scales of onion and garlic might have estrogen-like activities. Their estrogenic properties will be tested in view of the resemblance of the structure of the active substance to those of estradiol to be a phytoestrogen, binding to the estrogen receptor. This work will compare the estrogenic effects induced by estradiol and the plant extract in vivo and in vitro models of immature mice. To unravel the mechanism of estrogenic properties, these effects would reverse or abolish by pretreatment with an estrogen blocker suggesting that they are acting through estrogen receptors. Uterine wet weight/body weight ratios will be determined. Uterotrophic bioassay (increased epithelial cell height, number and gland development) and immunohistochemical assay for the estrogen receptor and proliferative marker Ki67 and uterine contractility will be investigated. The present study will try to test the estrogenic effects of outer scales of onion and garlic in experimental animals hoping to find that they can be used for the replacement therapy and management of hormonal disturbance. Adjustment of doses will be tried to avoid side effects when these plants are used in folk medicine, and in further studies, they can also be formulated in suitable pharmaceutical formulations. In the future, we plan to carry out pre-clinical and clinical trials for adopting pharmaceutical dosage forms with maximum efficacy and minimum side effects that can be prescribed to patients. 
Publishing Year : 1428 AH
2007 AD 
Sponsor Name : King Abdulaziz University 
Sponsorship Year : 1428 AH
2007 AD 
Added Date : Sunday, June 27, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبد المنعم الحياني الحيانيAl-Hayani, Abdulmonem Al-HayaniInvestigatorDoctorate 

Files

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 27154.docx docx 

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