Document Details

Document Type : Project 
Document Title :
Study the effect of nutmeg Nutmeg Myristica fragrans on jobs and behavioral Alkimu vital and histological structure in laboratory mice
دراسة تأثير جوزة الطيب Nutmeg Myristica fragrans على الوظائف السلوكية والكيمو حيوية والتركيب النسيجي في الفئران المعملية
 
Document Language : Arabic 
Abstract : Nutmeg seeds of common materials to use and frequently used in the Kingdom of Saudi Arabia and many countries of the world, in the medication. However, the necessary studies to ensure the effectiveness of these seeds and the risks that may be carried by the indiscriminate use is not available in spite of adverse effects is excluded. The study was conducted on mice of the type of MFI to study the toxicity of acute and chronic toxicity of the extract under the water to plant the seeds of nutmeg on the weight of the mice and the locomotor activity and aggressive behavior. The study also focused on the impact of this extract on the histological and biochemical signs of both liver and kidney and heart. In these experiments mice were injected into the peritoneal cavity of the seed extract at doses equivalent to 20, 40 and 80 mg of extract per kg of the weight of the animal. Injection has been a one-time scale for three groups to study the toxicity of acute and daily for six weeks in the other groups to study the toxic effect of the extract under chronic. And appointed group was injected daily for two weeks after being injected with vitamin C extract of nutmeg for a period of six weeks to study the ability of this vitamin to neutralize the effects of extract of nutmeg. Officer groups have been used for both studies were injected with physiological saline solution concentration of 0.9% instead of the nutmeg seed extract, for the same duration experiments. The study showed that injecting mice of type MFI Palmstkhals water the seeds of nutmeg to a single dose has been no statistically significant change on any of the measurements of motor activity and aggressive behavior compared to the control group. And also did not result from injection daily for six weeks any toxic effects on the statistical significance of body weight and locomotor activity or aggressive behavior compared to the control group. On the job biochemical results showed that the extract of nutmeg has led to a lack of statistically significant in both the overall level of protein and the level of albumin and high statistically significant in each of the enzyme SGPT and enzyme SGOT and enzyme LDH has also led to an increase statistically significant in the level of urea in the blood and the lack of a statistically significant in the level of creatinine in the blood. Upon microscopic examination of tissue sections showed that the extract of the seeds of nutmeg latest pathological changes (pathological) in the liver tissue degeneration in the form of aqueous and fatty degeneration and the change in the distribution of chromatin granules in the nuclei of cells and adhesion molecules Bjdr. This was less pathological changes in the group that injected vitamin C after treatment with extract of nutmeg. However, the nutmeg extract had no significant effect on the tissues of kidney and heart muscle. And it can be concluded from this study that the aqueous extract of the seeds of nutmeg dose used (20, 40 and 80 mg of extract per kg of body weight) has no toxic effect is clear on the behavior of mice of the type of MFI, but it has a toxic effect on the liver and functions of chemical vital to the College The heart muscle and that vitamin C may be beneficial in the treatment of these effects are harmful, but more studies needed and different doses can even cut it. And prefers to other studies using higher doses of the extract, nutmeg, as well as using the effective factors in an abstract individual. And clinical studies on users of nutmeg may be of great benefit. 
Publishing Year : 1422 AH
2002 AD 
Sponsor Name : kau 
Sponsorship Year : 1422 AH
2002 AD 
Added Date : Wednesday, April 30, 2008 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
منصور عطية الحازميalhazmi, mansour attiaInvestigatorDoctorate 

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