Document Details
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Project |
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Document Title |
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Studies on the effectiveness of cyclosporine - a factor of immunosuppression in the implants college. دراسات عن كفاءة السيكلوسبورين - أ كعامل كبت مناعي في غرسات الكلية. |
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Document Language |
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Arabic |
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Abstract |
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Has been studied for clinical use Cyclosporin - A in kidney transplants carefully in terms of efficacy and safety. The study focused on assessing changes in the characteristics and immunological and biochemical Alheimatulogih after the use of cyclosporine - and its relationship to a clinical Blastjabh in patients on the one hand, as well as their relationship to the level of cyclosporine - a plasma on the other.
Mqana also conducted among patients who were treated with prescription triglycerides (Cyclosporin - A, Berdenzulun, azathioprine) and among patients who were treated with conventional prescription (without cyclosporine - a.)
The number who were included in the search is 166 people, including 18 healthy the rest are patients with chronic renal failure has been divided into two groups: the first included 22 patients still in Antdhar the process of agriculture, and the second included 76 patients who underwent the process of agriculture, which is also divided into longitudinal group the 28 patients and a retrospective of the 48 patients.
And start the study of consecutive cases of group before the transplant, then continue for some time after the operation.
The number of patients who were treated with triple prescription 57 patients, and the rest and the 19 was treated with conventional prescription.
This has been Manadharh cyclosporine - a general way analysis by fluorescent polarization immune system T. De. X also has his debate in the blood of some cases.
This has resulted in the summary results and conclusions from the following:
1 - high concentrations is a normal urea, creatinine, phosphorus, and yeasts phosphorus, alkaline, and the rate of deposition of red cells, receptors, interleukin -2 dissolved in the serum patients with renal failure the final. The amounts of hemoglobin and Hema Tochrit and balls of red and white single-core and found low below normal. These levels return to normal value after the transplant.
And return characteristics of biochemical characteristics with remarkable speed by Alheimatulogih.
2 - show that the high values of the enzymes alkaline phosphorus and mononuclear leukocytes in the period prior to planting is the factor of acute Munther expulsion after the operation.
3 - There is no relationship between the level of Alsekspourin -1 in plasma and the therapeutic responses. There is also no correlation between the level of Alsakloren-1 and the survival of the implant.
There was also no significant difference between the level of cyclosporine-1 and between any of the immunological characteristics that have been studied and is generally due to the large size of the ripples in the level of Alsellosporan -1 need to careful observation of each individual.
4 - Aove treatment prescription for a long triple to a significant increase in the level of uric acid and blood Alchollstrulauskr random and seemed to be the effect of cyclosporine -1 in the absence of increases in patients who were treated without it.
The largesse has not side effects of cyclosporine-1 and immunological characteristics Alheimatulogih.
5 - The immunological characteristics of both in patients with renal failure or the ultimate in healthy individuals who were included in the search were in the normal rates but the rates of CD 3 +4 4 +4 CD DHL AOL 0.1 and interleukin -2 receptor Almjmuahalawly was dissolved in a high rise Mhoza compared to healthy people who have been studying. This indicates that there are some of the immune activation in patients with renal failure the final.
6 - Most cases of acute rejection occurred in the first two months after the transplant creatinine accompanied by an increase in interleukin -2 receptor and soluble, neutral and white cells and a decrease in the level of sodium.
7 - The rates were the lives of the general and patients in the group tracking implants are excellent (and a half years) increased by 96.4% and 92.9 respectively.
The rates were Almadyt best for those who planted them kidneys from living donors (100% and 100, respectively) than those who received kidneys from Vakadialehiah (90% and 80% respectively).
8 - has been associated with plasma concentration of 50-150 nanograms per ml of the cyclosporine -1 functions well for the implants.
It also acquitted of the existence of any general acute poisoning.
In conclusion, I have confirmed these results that although the nature of anomalies and the level vagus of ciclosporin -1 blood it prevented any direct correlation with his responses to clinical as well as with other characteristics Elan use it dose used in this study associated with higher rates of life of patients and the survival of implants with no the effects of poisoning the year, but an increase in cholesterol and uric acid and sugar in the blood long-term factors may be an advocate for a gouty arthritides, and cardiovascular disease and diabetes. |
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Publishing Year |
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1411 AH
1991 AD |
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Added Date |
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Wednesday, April 30, 2008 |
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Researchers
| سميرة إبراهيم إسلام | Islam, sameirah Ibrahim | Investigator | Doctorate | |
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